Good evening sir. I am ramesh age 40. I am a pharmacist and rural doctor. I am suffering from dysthymia, anxiety neurosis, short temper and angry (soft mania) last 18 years. I consult psychiatrist and tried ssris, snris.due to side effects every 3 months I discontinued the medicines. I have also overactive bladder, l5-s1 slipped disc, gynecomastia,abnormal triglycerides, cholesterol, my weight is 83 kgs, stomach is 38 inches. But no sugar, b.p. No heart problems, thyroid.4 months back psychiatrist gave me duloxetine20, oleanz 2.5 mg,divalproex500 mg. Due to sexual side effect I discontinued. I try paroxetine, mirtazapine,desvenlafaxine, venlafaxine many more. According lancet journal2020 I know very effective and tolerable antidepressants simuntenuosuly agomelatine, amitriptyline,escitalopram, mirtazapine,paroxetine, venlafaxine.my favorite drug is escitalopram. But I taking escitalopram I got stomach upset and loose stool .is loose stool is dangerous. How many weeks overcome this problem sir. Is olanzapine or quetiapine safe for my body. I fear lithium horrible side effects. Jam live in village .here no psychiatrists. I lose my business. I am very very lazy, severe procrastinator, no hope, no energy insomnia, nightmares,etc, etc. For overactive bladder can I take tab mirabegron with antidepressants, tab solifenacin with olanzapine, quetiapine.psychiatrist gave me tab modafinil for my lazy. Sir I request you to which antidepressant, and which antipsychotic ,mood stabilizer is effective for my problems. Last 2 months I have no take ssris, snris.i am a pharmacist no problem to you. please sir give treatment guideline for me.